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(3) they permit binding of heparin to its antidote, protamine (polycationic protein from salmon sperm). If protamine is given in heparin-induced bleeding, the effect of heparin is immediately reversed. For effective thromboprophylaxis, a low dose of 5000 IU is injected s. c. two to three times daily.
The typical gout attack consists of a highly painful inflammation of the first metatarsophalangeal joint (“podagra”). Gout attacks are triggered by precipitation of sodium urate crystals in the synovial fluid of joints. During the early stage of inflammation, urate crystals are phagocytosed by polymorphonuclear leukocytes (1) that engulf the crystals by their ameboid cytoplasmic movements (2). |
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