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(3) they permit binding of heparin to its antidote, protamine (polycationic protein from salmon sperm). If protamine is given in heparin-induced bleeding, the effect of heparin is immediately reversed. For effective thromboprophylaxis, a low dose of 5000 IU is injected s. c. two to three times daily.
Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races.

 

The typical gout attack consists of a highly painful inflammation of the first metatarsophalangeal joint (“podagra”). Gout attacks are triggered by precipitation of sodium urate crystals in the synovial fluid of joints. During the early stage of inflammation, urate crystals are phagocytosed by polymorphonuclear leukocytes (1) that engulf the crystals by their ameboid cytoplasmic movements (2).
d-Tubocurarine is given by i. v. injection (average dose approx. 10 mg). It binds to the endplate nicotinic cholinoceptors without exciting them, acting as a competitive antagonist towards ACh. By preventing the binding of released ACh, it blocks neuromuscular transmission. Muscular paralysis develops within about 4 min. d-Tubocurarine does not penetrate into the CNS.

 

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